王可，博士后

研究方向：

1. 主要从事天然产物纯化、合成、结构修饰及活性研究

2. 抗肿瘤药物的设计、合成、结构修饰及活性研究

3. 癌症进程中的肿瘤微环境与脂质组分变化的关系

教育背景：

2010.09-2016.06  中国药科大学  药物化学系  硕博连读

2006.09-2010.07  中国药科大学  药学系  学士

工作经历：

2025.03至今  博士后  南京工业大学药学院

2016.09-2023.07  访问学者  中国医药大学（台湾）

代表性科研成果：

Ke Wang, Pei-Yin Liao, Cian-Ru Yang, Yu-Ting Su, Ping-Ching Wu, Yang-Chang Wu, Yao-Ching Hung, Najim Akhtar, Hsueh-Chou Lai* and Wen-Lung Ma*. Linoleate-Pazopanib Conjugation as Active Pharmacological Ingredient to Abolishes Hepatocellular Carcinoma Growth. Frontiers in Pharmacology, 2024 (DOI:10.3389/fphar.2023.1281067).

Ke Wang, Juan-Cheng Yang, Yeong-Jiunn Jang, Guan-Yu Chen, Ya-Jing Zhang, Yun-Hao Dai, Da-Yong Zhang,* Yang-Chang Wu.* 19-(Benzyloxy)-19-oxojolkinolide B (19-BJB), an ent-abietane diterpene diepoxide, inhibits the growth of bladder cancer T24 cells through DNA damage. Plos One, 2021, 16(3): e0248468.

Ke Wang, Yang-Chang Wu, Juan-Cheng Yang, Meng-Han Zhang, Mohamed El-Shazly, Da-Yong Zhang,* Xiao-Ming Wu*. Synthesis of novel 3,19-dihydroxyjolkinolides and related derivatives starting from andrographolide. Synthesis-Stuttgart, 2016, 48, 2245-2254.

Daniel Winardi, Pei-Yi Chu, Guan-Yu Chen, Ke Wang, Wei-Yu Hsu, Ching-Liang Hsieh, Yung-Hsiang Chen, Yang-Chang Wu,* and Juan-Cheng Yang*. Novel Aurora A Kinase Inhibitor Fangchinoline Enhances Cisplatin–DNA Adducts and Cisplatin Therapeutic Efficacy in OVCAR-3 Ovarian Cancer Cells-Derived Xenograft Model. Int. J. Mol. Sci. 2022, 23, 1868.

Fen-Lan Wu, Pei-Yi Chu, Guan-Yu Chen, Ke Wang, Wei-Yu Hsu, Azaj Ahmed, Wen-Lung Ma, Wei-Chung Cheng, Yang-Chang Wu*, Juan-Cheng Yang*. Natural Anthraquinone Compound Emodin as a Novel Inhibitor of Aurora A Kinase: a Pilot Study. Chemical Biology & Drug Design. 2021.

Yan-Cheng Liou, Yan-An Lin, Ke Wang, Juan-Cheng Yang, Yeong-Jiunn Jang*, Wen wei Lin, Yang-Chang Wu*. Synthesis of novel spiro-tetrahydroquinoline derivatives and evaluation of their pharmacological effects on wound healing. Int. J. Mol. Sci. 2021, 22(12), 6251.

Yan Luo, Ke Wang, Meng-Han Zhang, Da-Yong Zhang,* Yang-Chang Wu,* Xiao-Ming Wu, Wei-Yi Hua. Synthesis of new ent-labdane diterpenes derivatives from andrographolide and evaluation of anticancer activity. Bio. Med. Chem. Lett., 2015, 25, 2421-2424.

Chang-Zhen Zhu, Ke Wang, Meng-Han Zhang, Da-Yong Zhang,* Yang-Chang Wu, Xiao-Ming Wu, Wei-Yi Hua. Efficient synthesis of jolkinolides A and B from steviol. Synthesis-Stuttgart, 2014, 46, 2574-2578.

E-mail：waker603@njtech.edu.cn