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王玉斌
阅读次数:     发布时间:2017-04-19


王玉斌,副研究员,硕士研究生导师, 药物化学教研室副主任

教育背景:

2003.9-2008.7 中国药科大学 药物化学 博士

1999.9-2003.7 中国药学大学 药物制剂 学士

工作经历:

2013.7至今 南京工业大学 药学院 副研究员

2013.7-2014.7 美国哈佛大学 访问学者

2010.5-2013.7 南京工业大学 药学院 助理研究员

2008.7-2010.5 台湾旭富医药科技有限公司南京研发中心 工程师

研究方向:

1、抗肿瘤新药的设计合成和生物活性研究;

2、原料药绿色合成工艺开发;

3、仿制药的注册申报,包括QbD理念下的合成工艺开发、产业化中试放大、药品质量研究;

4、全过程的杂质研究与控制,从原料药到制剂的杂质谱研究,涵盖杂质的分离与鉴定、基因毒性杂质研究、元素杂质研究等。

近期发表的部分论文:

1S. Xia, Y. Jian, L. Zhang, C. Zhang, Y. An* and Y. Wang*, Visible-light-promoted N–H functionalization of O-substituted hydroxamic acid with diazo esters, Rsc Advances. 2023, 13, 14501-14505.

2X. Liu+, Y. Shen+, C. Lu, Y. Jian, S. Xia, Z. Gao, Y. Zheng, Y. An*, Y. Wang*, Visible-light-driven PhSSPh-catalyzed regioselective hydroborylation of α,β-unsaturated carbonyl compounds with NHC-boranes, Chemical Communications. 2022, 58, 8380-8383.

3H. Wan, S. Xia, X. Liu, Y. Jian, Y. An*, Y. Wang*, Synthesis of spirocyclic oxazole derivatives from 2-aryldene cycloalkanones and α-halohydroxamates, Organic & Biomolecular Chemistry . 2022, 20, 4293-4297.

4P. Lu,  X. Liu, X. Yuan, M. He, Y. Wang*, Q. Zhang , P. OuyangDiscovery of a novel NEDD8 Activating Enzyme Inhibitor with Piperidin-4-amine Scaffold by Structure-Based Virtual ScreeningACS Chemical Biology2016111901−1907

5P. Lu, Y. Guo, L. Zhu, Y. Xia, Y. Zhong, Y. Wang*; A novel NAE/UAE dual inhibitor LP0040 blocks neddylation and ubiquitination leading to growth inhibition and apoptosis of cancer cellsEuropean Journal of Medicinal Chemistry2018154294-304

6X. Yuan, Y. Xia, Lu P, L. Zhu, Y. Zhong, Y. Wang*; Synthesis and evaluation of 1H-pyrrole-2,5-dione derivatives as cholesterol absorption inhibitors for suppressing the formation of foam cells and inflammatory responseBioorganic & Medicinal Chemistry2018261435-1447

7Y. Yuan, P. Lu, X. Xue, H. Qin, C. Fan, Y. Wang*, Q. Zhang; Discovery of 2-azetidinone and 1H-pyrrole-2,5-dione derivatives containing sulfonamide group at the side chain as potential cholesterol absorption inhibitorsBioorganic & Medicinal Chemistry Letters201626849–853

8Y. Wang, H. Liu, P. Lu, R. Mao, X. Xue, C. Fan, J. She; Design, Synthesis, and In Vitro Evaluation of Novel 3,7-Disubstituted Coumarin Derivatives as Potent Anticancer AgentsChemical Biology & Drug Design201586637-647

9P. Lu, Y. Wang*, P. Ouyang, J. She, M. He3D-QSAR Based Pharmacophore Modeling and Virtual Screening for Identification of Novel G Protein-Coupled Receptor40 Agonists, Current Computer-Aided Drug Design2015 1151-56 Lu P, Y. Wang*, Ma B, She JX, Zhang Q, He MF, Liu Y; Pharmacophore-Based Discovery of New Human DihydroorotateDehydrogenase InhibitorMedicinal Chemistry201410402-408

10X. Xue, Y. Wang*, P. Lu, H. Shang, J. She, L. Xia, H. Qian, W. Huang; Synthesis and in Vitro Evaluation of 1,3,4Thiadiazol-2-yl UreaDerivatives as Novel AChE Inhibitors, Chemical & Pharmaceutical Bulletin2014626),524-527

11C. Fan, Y. Wang*, P. Lu, X. Xue, J. She; Synthesis and Biological Evaluation of Novel N-[(7-pyridin-4-yl-2, 3-dihydro-benzofuran-2-yl)Methyl]-(4-methyl-1, 2, 3-thiadiazole-5-yl) Formamide as a Potent Immunosuppressant Agent; Letters in Drug Design & Discovery201411375-379

12L. Zhu, P. Lu, L. Gong, C. Lu, M. Li, Y. Wang*Design, Synthesis, and Biological Evaluation of 4-amino Substituted 2H-chromen-2-one Derivatives as an NEDD8 Activating Enzyme Inhibitor in Pancreatic Cancer Cells, Medicinal Chemistry, 2020, 16, 969-983

13Y. Xia, L. Zhu, X. Yuan, Y. Wang*; Synthesis and Evaluation of 2-Azetidinone and 1H-Pyrrole-2,5-dione Derivatives as Cholesterol Absorption Inhibitors for Reducing Inflammation Response and Oxidative Stress, Chem. Biodiversity 2019, 16, e1800189

E-mail: wyb5393@163.com