朱静怡，副教授，硕士生导师。
长期从事基于超支化聚合物的有机、无机纳米杂化材料的构建、组装及其生物医学应用研究。致力于新型智能化生物材料的设计合成、表征及肿瘤生物学应用探索，目前已在Coord. Chem. Rev.、ACS Appl. Mater. Interfaces、Biomaterials、Nanoscale、Biomater. Sci.、Int. J. Nanomed.、J. Nanobiotechnol.等国际期刊上发表SCI论文40余篇，影响因子总和超过300，其中影响因子大于6.0的SCI论文26篇，申请中国发明专利9项，已授权6 项。
教育/工作经历：
2020/07至今，南京工业大学，药学院，副教授
2017/03-2020/07，南京工业大学，药学院，讲师
2013/03-2017/03，东华大学，仿生材料，硕博连读，博士
2015/09-2016/09，美国南加州大学，Keck医学院，联合培养博士研究生
2014/05-2014/07，葡萄牙马德拉大学，短期访学
2011/09-2013/03，东华大学，有机化学，硕博连读硕士阶段
2007/09-2011/06，湖北大学，应用化学，学士
研究方向：生物纳米技术
以各种基于树状大分子或生物相容性高分子修饰或组装的多种纳米颗粒为医学平台，研究癌症的早期诊断和治疗；
贵金属基光热转换纳米材料的构建及光热治疗应用；
核素标记纳米体系的设计及其核医学成像和放射性治疗；
主持科研项目：
2019/01-2021/12国家自然科学基金青年科学基金项目（21807059）；
2018/07-2021/06江苏省自然科学基金青年基金项目（BK20180711）；
2017/09-2019/08江苏省高等学校自然科学研究面上项目（17KJB350005）；
2019/12-2020/12南京留学人员科技创新项目；
2020/12-2021/12上海市轻质结构复合材料重点实验室开放课题（2232020A4-07）；
所获荣誉：
2018年获“中国复合材料学会优秀博士学位论文提名奖”；
2019年获“第四届西浦全国大学教学创新大赛年度教学创新参与奖”；
2017年获“第十三届全国医药卫生青年科技论坛”药学组优秀论文奖；
代表性论文：
1. Benqing Zhou, Jinxing Liu, Meiai Lin*, Jingyi Zhu*, Wei R*. Chen. Recent advances in immunotherapy, immunoadjuvant, and nanomaterial-based combination immunotherapy. Coordination Chemistry Reviews, 2021, 442, 214009. (IF 24.833)
2. Jingyi Zhu, Junxing Yang, Lingzhou Zhao, Pingping Zhao, Jiqin Yang, Jinhua Zhao, Wenjun Miao. 131I-Labeled multifunctional polyethylenimine/doxorubicin complexes with pH-controlled cellular uptake property for enhanced SPECT imaging and chemo/radiotherapy of tumors. International Journal of Nanomedicine, 2021, 16, 5167-5183. (IF 7.033)
3. Jingyi Zhu,* Lingzhou Zhao, Pingping Zhao, Junxing Yang, Jianhui Shi, and Jinhua Zhao.* Charge-conversional polyethylenimine-entrapped gold nanoparticles with 131I-labeling for enhanced dual mode SPECT/CT imaging and radiotherapy of tumors. Biomaterials Science, 2020, 8(14), 3956-3965. (IF 7.59)
4. Fengshuo Wang#, Jingyi Zhu# (Co-1st author), Yongtao Wang*, Jingchao Li*. Recent advances in engineering nanomedicines for second near-infrared photothermal-combinational immunotherapy. Nanomaterials, 2022, 12 (10), 1656. (IF 5.719)
5. Yijing Zhang#, Jingyi Zhu# (Co-1st author), Haitao Sun*, Jingchao Li*. Modulation of tumor hypoxia and redox microenvironment using nanomedicines for enhanced cancer photodynamic therapy. Applied materials today, 2022, 29, 101687. (IF 8.663)
6. Lingdan Kong#, Jingyi Zhu# (Co-1st author), Hongxing Su, Lingzhou Zhao, Yi Lu*, Meilin Zhu*, Wenjie Sun*. Phenylboronic acid conjugated multifunctional nanogels with 131I-labeling for targeted SPECT imaging and radiotherapy of breast adenocarcinoma. Frontiers in Bioengineering and Biotechnology, 2022, 10, 973141. (IF 6.064)
7. Jingyi Zhu, Lingzhou Zhao, Junxing Yang, Liang Chen, Jianhui Shi, Jinhua Zhao, and Xiangyang Shi. 99mTc-Labeled Polyethylenimine-entrapped gold nanoparticles with pH-responsive charge conversion property for enhanced dual mode SPECT/CT imaging of cancer cells. Langmuir, 2019, 35(41), 13405-13412. (IF 4.331)
8. Jingyi Zhu, Hongsheng Li, Zhijuan Xiong, Mingwu Shen, Peter S. Conti, Xiangyang Shi, Kai Chen. Polyethyleneimine-coated manganese oxide nanoparticles for targeted tumor PET/MR imaging. ACS Applied Materials & Interfaces, 2018, 10(41), 34954-34964. (IF 10.383)
9. Jingyi Zhu, Guoying Wang, Carla S. Alves, Helena Tomás, Zhijuan Xiong, Mingwu Shen, João Rodrigues, Xiangyang Shi. Multifunctional dendrimer-entrapped gold nanoparticles conjugated with doxorubicin for pH-responsive drug delivery and targeted CT imaging. Langmuir, 2018, 34(41), 12428-12435. (IF 4.331)
10. Qi Su†, Changcun Liu†, Jingyi Zhu*, Mengbin Ding, Zhen Zhang, Jingchao Li* and Qin Zhang*. Albumin-stabilized manganese oxide/semiconducting polymer nanocomposites for photothermal-chemodynamic therapy of hepatic carcinoma. Frontiers in Bioengineering and Biotechnology, 2022, 10, 919235. (IF 6.064)
11. Jingyi Zhu, Lingzhou Zhao, Yongjun Cheng, Zhijuan Xiong, Yueqin Tang, Mingwu Shen, Jinhua Zhao, Xiangyang Shi. Radionuclide 131I-labeled multifunctional dendrimers for targeted SPECT imaging and radiotherapy of tumors. Nanoscale, 2015, 7, 18169-18178. (IF 8.307)
12. Jingyi Zhu, Zhijuan Xiong, Mingwu Shen, Xiangyang Shi. Encapsulation of doxorubicin within multifunctional gadolinium-loaded dendrimer nanocomplexes for targeted theranostics of cancer cells. RSC Advances, 2015. 5(38), 30286-30296. (IF 4.036)
13. Jingyi Zhu, Fanfan Fu, Zhijuan Xiong, Mingwu Shen, Xiangyang Shi. Dendrimer-entrapped gold nanoparticles modified with RGD peptide and alpha-tocopheryl succinate enable targeted theranostics of cancer cells. Colloids and Surfaces B: Biointerfaces, 2015, 133, 36-42. (Front Cover, IF 5.999)
14. Jingyi Zhu, Linfeng Zheng, Shihui Wen, Yueqin Tang, Mingwu Shen, Guixiang Zhang, Xiangyang Shi. Targeted cancer theranostics using alpha-tocopheryl succinate-conjugated multifunctional dendrimer-entrapped gold nanoparticles. Biomaterials, 2014. 35(26), 7635-7646. (IF 15.304)
15. Pingping Zhao, Junxing Yang, Jianhui Shi, Jingyi Zhu*. Construction and application of dendrimer-based SPECT imaging agent. Progress in Chemistry, 2021, 33(3), 394-405. (IF 1.044)
16. Junxiu Zhang, Jingyi Zhu (Co-1st author), Lingzhou Zhao, Ke Mao, Qing Gu, Dongli Li, Jinhua Zhao, Xingwei Wu. RGD-Modified multifunctional nanoparticles encapsulating salvianolic acid A for targeted treatment of choroidal neovascularization. Journal of Nanobiotechnology, 2021, 19 (1), 196. (IF 9.429)
17. Lingzhou Zhao, Jingyi Zhu (Co-1st author), Jiali Gong, Ningning Song, Shan Wu, Wenli Qiao, Jiqin Yang, Meilin Zhu, Jinhua Zhao. Polyethylenimine-based theranostic nanoplatform for glioma-targeting single-photon emission computed tomography imaging and anticancer drug delivery. Journal of Nanobiotechnology, 2020, 18(1), 143. (IF 9.429)
18. Lingzhou Zhao, Jingyi Zhu (Co-1st author), Tiantian Wang, Changcun Liu, Ningning Song, Shan Wu, Wenli Qiao, Jiqin Yang, Meilin Zhu, Jinhua Zhao. A novel Buthus martensii Karsch chlorotoxin derivative for glioma SPECT imaging. New Journal of Chemistry, 2020, 44(35), 14947-14952 (IF 3.925)
19. Yan Xing, Jingyi Zhu (Co-1st author), Lingzhou Zhao, Zhijuan Xiong, Yujie Li, San Wu, Gitasha Chand, Xiangyang Shi, Jinhua Zhao. SPECT/CT imaging of chemotherapy-induced tumor apoptosis using 99mTc-labeled dendrimer-entrapped gold nanoparticles. Drug Delivery, 2018, 25(1), 1384-1393. (IF 6.819)
20. Lingzhou Zhao, Jingyi Zhu (Co-1st author), Yongjun Cheng, Zhijuan Xiong, Yueqin Tang, Lilei Guo, Xiangyang Shi, Jinhua Zhao. Chlorotoxin-conjugated multifunctional dendrimers labeled with radionuclide 131I for single photon emission computed tomography imaging and radiotherapy of gliomas. ACS Applied Materials & Interfaces, 2015, 7, 19798-19808. (IF 10.383)
21. Yongjun Cheng, Jingyi Zhu (Co-1st author), Lingzhou Zhao, Zhijuan Xiong, Yueqin Tang, Changcun Liu, Lilei Guo, Wenli Qiao, Xiangyang Shi, Jinhua Zhao, 131I-labeled multifunctional dendrimers modified with BmK CT for targeted SPECT imaging and radiotherapy of gliomas. Nanomedicine, 2016, 11(10), 1253-1266. (IF 6.096)
22. Ran Lu, Jingyi Zhu (Co-1st author), Chaowen Yu, Zhonglin Nie and Yong Gao. Cu3BiS3 nanocrystals as efficient nanoplatforms for CT imaging guided photothermal therapy of arterial inflammation. Frontiers in Bioengineering and Biotechnology, 2020, 8, 981. (IF 6.064)
专利
1. 朱静怡，赵平平，杨军星。131I标记聚乙烯亚胺/阿霉素络合物及其制备和应用。中国发明专利，2022/04/22，ZL 201911318070.0。（已授权）
2. 朱静怡，杨军星。功能化聚乙烯亚胺包裹纳米金颗粒复合材料及其制备方法。2021/09/28，中国发明专利，ZL 201910444963.3。（已授权）
3. 朱静怡，赵平平，储建林，杨军星。pH敏感的131I标记金纳米星及其制备方法和应用。2021/05/28，中国发明专利，ZL 201911317204.7。（已授权）
4. 史向阳，朱静怡，陈凯，李洪生。一种64Cu标记叶酸靶向的功能化聚乙烯亚胺稳定的四氧化三锰纳米颗粒的制备方法。2019/03/08，中国发明专利，ZL 201610131097.9。（已授权）
5. 史向阳，朱静怡，熊智娟，赵晋华，赵凌舟。一种放射性核素131I标记的叶酸靶向的多功能树状大分子的制备方法。2018/01/05，中国发明专利，ZL 201510171048.3。（已授权）
6. 史向阳，朱静怡。一种alpha-TOS负载的树状大分子包裹的纳米金颗粒的制备方法。2014/10/15，中国发明专利，ZL 201210593688. X。（已授权）
7. 朱静怡，杨军星，缪文俊，岳林杰，何灵秀，柯锦平。功能化聚乙烯亚胺纳米复合材料的制备及其诊疗应用。中国发明专利，专利申请日：2022.10.19，专利申请号：202211280770.7。
Email: zhujy1210@njtech.edu.cn； zhujy1210@163.com
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