周国春，教授，博士生导师。

研究方向：药物化学，化学生物学

教育背景：

1997.9 - 2000.7  博士 中国科学院上海药物研究所；1986.9 - 1989.6  硕士， 兰州大学化学系；1982.9 -1986.7  本科 南京大学 化学系

工作经历：

2010.3至今  教授、课题负责人、博士生导师 南京工业大学药学院

2005.3－2010.3  研究员、课题组长 (PI)、博士生导师 中国科学院广州生物医药与健康研究院，研究方向：药物化学，化学生物学

2002.8 – 2005.2  Research Associate 美国爱因斯坦医学院生物化学系

2001.2 – 2002.8  博士后 美国 麻省理工学院 (MIT) 癌症研究中心和约翰霍普金斯大学医学院分子药理系

2000.8 - 2001.1 博士后 美国乔治城大学医学中心药物发现研究部

1989.6 - 1997.8  助理工程师、工程师 江苏省农药研究所

2021年以来代表性论文：

1. Guang-Feng Zhou, Weiyi Qian, Feng Li, Ren-Hua Yang, Na Wang, Chang-Bo Zheng, Chun-Yan Li, Xue-Rong Gu, Liu-Meng Yang, Jinsong Liu, Si-Dong Xiong, Guo-Chun Zhou^*, Yong-Tang Zheng “Discovery of ZFD-10 of a pyridazino[4,5-b]indol-4(5H)-one derivative as an anti-ZIKV agent and a ZIKV NS5 RdRp inhibitor” Antiviral Res 2023, 214, 105607.

2. Guang-Feng Zhou, Feng Li, Jian-Xia Xue, Weiyi Qian, Xue-Rong Gu, Chang-Bo Zheng, Chunyan Li, Liu-Meng Yang, Si-Dong Xiong, Guo-Chun Zhou*, Yong-Tang Zheng “Antiviral effects of the fused tricyclic derivatives of indoline and imidazolidinone on ZIKV infection and RdRp activities of ZIKV and DENV” Virus Res. 2023, 326, 199062.

3. Ran Chen, Rachele Francese, Na Wang, Feng Li, Xia Sun, Bin Xu, Jinsong Liu, Zhuyun Liu, Manuela Donalisio, David Lembo, Guo-Chun Zhou*, “Exploration of novel hexahydropyrrolo[1,2-e]imidazol-1-one derivatives as antiviral agents against ZIKV and USUV”, Eur. J. Med. Chem. 2023, 248, 115081.

4. Yu Gu, Guo-Chun Zhou*, Selective Acetylation of C4’- and C5-Hydroxyl groups of Naringenin Derivatives, Indian J. Heterocycl. Chem. 2022, 32, 278-284.

5. Weiyi Qian, Guang-Feng Zhou, Xintong Ge, Jian-Xia Xue, Chang-Bo Zheng, Liu-Meng Yang, Xue-Rong Gu, Chunyan Li, Si-Dong Xiong, Yong-Tang Zheng, Guo-Chun Zhou*, “Discovery of dehydroandrographolide derivatives with C19 hindered ether as potent anti-ZIKV agents with inhibitory activities to MTase of ZIKV NS5”, Eur J Med Chem. 2022, 243, 114710.

6. Weiyi Qian, Jian-Xia Xue, Jinxin Xu, Feng Li, Guang-Feng Zhou, Fang Wang, Rong-Hua Luo, Jinsong Liu, Yong-Tang Zheng, Guo-Chun Zhou*, “Design, synthesis, discovery and SAR of the fused tricyclic derivatives of indoline and imidazolidinone against DENV replication and infection” Bioorg Chem 2022, 120, 105639.

7. Jie Kai Tan, Ran Chen, Regina Ching Hua Lee, Feng Li, Kun Dai, Guo-Chun Zhou*, Justin Jang Hann Chu “Discovery of novel andrographolide derivatives as antiviral inhibitors against human enterovirus A71” Pharmaceuticals 2022, 15, 115.

8. Zhuyun Liu, Xiaoping Wu, Kun Dai, Renkai Li, Jinming Zhang, Dekuan Sheng, Simon Ming-Yuen Lee, George Pak-Heng Leung,Guo-Chun Zhou*, Jingjing Li “The new andrographolide derivative AGS-30 induces apoptosis in human colon cancer cells by activating a ROS-dependent JNK signalling pathway” Phytomedicine 94 (2022) 153824.

9. Arpita Dey, Ran Chen, Feng Li, Subhamita Maitra, Jean-Francois Hernandez, Guo-Chun Zhou* and Bruno Vincent “Synthesis and characterization of andrographolide derivatives as regulators of αAPP processing in human cells” Molecules 2021, 26, 7660.

10.    Kun Dai, Jie Kai Tan, Weiyi Qian, Regina Ching Hua Lee, Justin Jang Hann Chu, Guo-Chun Zhou*“Discovery of 14S-(2’-chloro-4’-nitrophenoxy)-8R/S,17-epoxy andrographolide as EV-A71 infection inhibitor” Biochem Pharmacol 2021, 194, 114820.

11.    Mo-Yu Ding, Yuran Peng, Feng Li, Zheng-Qing Li, Decai Wang, Guo-Chun Zhou*, Ying Wang “Andrographolide derivative as antagonist of vitamin D receptor to induce lipidation of microtubule associate protein 1 light chain 3 (LC3)” Bioorg Med Chem 2021, 51, 116505.

E-mail: gczhou@njtech.edu.cn