2018年12月19日 星期三
 
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胡燚

  (yi),1975年9月生,教授,获省高校“青蓝工程”中青年学术带头人和南京工业大学“南工精英九思奖”等荣誉称号。2005年3月获得浙江大学有机化学专业博士学位,2012-2013年在美国斯克利普斯研究所(The Scripps Research Institute )Jin-Quan Yu教授课题组做访问学者研究工作。主要研究方向为生物催化、化学催化、生物-化学组合合成技术在生物炼制、药物及精细化学品等绿色合成中的应用研究。
讲授课程:

   《生物炼制》,《高等有机化学》与《药物合成反应》。
科研项目:

     作为负责人完成了国家863计划重大项目子课题—左旋帕罗醇的生物不对称合成技术(2011AA02A209)、国家自然科学基金青年基金项目—功能化离子液体修饰介孔材料在酶固定化中的应用研究(20906049),江苏省自然科学基金项目—生物乙醇脱水制乙烯高性能分子筛催化剂及其反应器研究(BK2009494),中石化科技开发项目—熔盐循环等温固定床数值模拟及中试实验研究(L411003),材料化学工程国家重点实验室重点项目—生物乙醇脱水制乙烯高性能分子筛催化剂复合改性和反应器设计研究(ZK200815),国家发改委高技术产业化项目—酶法生产百吨级左旋帕罗醇示范工程等项目的研究工作。目前承担国家自然科学基金面上项目—基于分子模拟的功能性离子液体化学修饰脂肪酶分子改造研究(21676143)。共发表SCI论文50余篇,获授权发明专利10余项。

近年来部分SCI论文:

(1) Ding Yan, Xiang Xinran, Gu Mengjie, Xu Haoran, Huang He*, Hu Yi*. Efficient lipase-catalyzed Knoevengael condensation: utilization of biocatalytic promiscuity for synthesis of benzylidene-indolin-2-ones. Bioprocess and Biosystems Engineering, 2016, 39: 125-131.

(2) 张川, 张鲁嘉, 张洋, 黄和, 胡燚*. 基于分子模拟的离子液体修饰Porcine pancreas脂肪酶催化性能和稳定性的相关研究. 化学学报, 2016, 74(1): 74-80.

(3) Li Xiujuan, Zhang Chuan, Li Shuang, Huang He*, Hu Yi*. Improving catalytic performance of Candida rugosa lipase by chemical modification with polyethylene glycol functional ionic liquids. Industrial & Engineering Chemistry Research, 2015, 54: 8072-8079.

(4) Ding Yan, Ni Xiao, Gu Meijie, Li Shuang, Huang He*, Hu Yi*. Knoevenagel condensation of aromatic aldehydes with active methylene compounds catalyzed by lipoprotein lipase. Catalysis Communication, 2015, 64: 101-104.

(5) Toba# Tetsuya, Hu Yi#, Tran AnhT, Yu Jinquan*. beta-C-(sp(3))-H arylation of alpha-hydroxy acid derivatives utilizing amino acid as a directing group. Organic Letters, 2015, 17: 5966-5969.(共同一作)

(6) Yigang Jia, Yang Zhang,Hongman Zhang, He Huang, Lujia Zhang,Yi Hu*. Prediction of lysine acetylation sites in Porcine pancreaslipase modified by the ionic liquids usingmolecular dynamics simulations. Lecture Notes in Electrical Engineering, 2015, 333: 365-379.

(7) 万晓梅张川, 余定华, 黄和胡燚*.  碳纳米管固定化酶. 化学进展, 2015, 27: 1251-1259.

(8) Liu Weiming, Hu Yi, Zhang Yang, Ma Yan, Huang He*. Enzymatic desymmetrization of 3-(4-fluorophenyl)glutaric anhydride|through enantioselective alcoholysis in organic solvents. Biotechnology & Bioprocess Engineering, 2014, 19:449-455.

(9) Liu Weiming, Ma Hongmin, Luo Jixing, Shen Wenhe, Xu Xian, Li Shuang, Hu Yi*, Huang He*. Efficient synthesis of L-tert-leucine dehydrogenase and formate dehydrogenase coexpressed in recombinant E. coli. Biochemical Engineering Journal, 2014, 91: 204-209

(10) Liu Weiming,. Luo Jixing, Zhuang Xiaojian, Li Shuang, Hu Yi*, Huang He*. Efficient preparation of enantiopure L-tert-leucine through immobilized penicillin G acylase catalyzed kinetic resolution in aqueous medium, Biochemical Engineering Journal, 2014, 83: 116-120.

(11) Hu Yi,Yang Jiao, Jia Ru, Ding Yan, Li Shuang, Huang He*. Chemical modification with functionalized ionic liquids: a novel method to improve the enzymatic properties of Candida rugosa lipase. Bioprocess and Biosystems Engineering, 2014, 37: 1617-1626.
(12) Ru Jia, Yi Hu*, He Huang*. Improving the catalytic performance of Porcine pancreatic lipase in the presence of [MMIm][MeSO4] with the modification of functional ionic liquids. Process Biochem., 2014, 49(4): 668-672.
(13) Bin Zou, Yi Hu*, Fengjie Cui, Ling Jiang, Dinghua Yu, He Huang*. Effect of surface modification of low cost mesoporous SiO2 carriers on the properties of immobilized lipase. J. Colloid. Interf. Sci., 2014, 417, 210.
(14) Ru Jia, Yi Hu*, Ling Jiang, He Huang*. Chemical modification for improving activity and stability of lipase B from Candida antarctica with imidazolium-

functional ionic liquids. Org. Biomol. Chem., 2013, 11, 7192.
(15) Ru Jia#, Yi Hu#, Luo Liu, Ling Jiang, Bin Zou, He Huang*. Enhancing catalytic performance of Porcine pancreatic lipase by covalent modification using functional ionic liquids. ACS Catal., 2013, 3, 1976.(共同一作)
(16) Bin Zou, Yi Hu, Ling Jiang, Jiao Yang, Ru Jia, He Huang*. Mesoporous material SBA-15 modified by amino acid ionic liquid to immobilize lipase via ionic bonding and cross-linking method. Ind. Eng. Chem. Res., 2013, 52, 2844.
(17) Jiao Yang, Yi Hu, Ling Jiang, Bin Zou, Ru Jia, He Huang*. Enhancing the catalytic properties of porcine pancreatic lipase by immobilization on SBA-15 modified by functionalized ionic liquid. Biochem. Eng. J., 2013, 70, 46.
(18) Xiangjun Jiang, Yi Hu, Lin Jiang, Bin Zou, He Huang*. Optimization of enzymatic synthesis of L-ascorbyl palmitate by solvent engineering and statistical experimental designs. Biotechnol. Bioproc. Eng., 2013, 18, 350.
(19) Xiangjun Jiang, Yi Hu, Lin Jiang, Jihong Gong, He Huang*. Synthesis of vitamin E succinate using Candida rugosa lipase in organic medium. Chem. Res. Chin. Univ., 2013, 29, 223.
(20) Yi Hu, Xiangjun Jiang, Suwen Wu, Ling Jian, He Huang*.Synthesis of vitamin E succinate by interfacial activated Candida rugosa lipase encapsulated in sol-gel materials. Chin. J. Catal., 2013, 34, 1608.
(21) Xiaochen Wang, Yi Hu, Samuel Bonacorsi, Yang Hong, Richard Burrell, Jinquan Yu*. Pd(II)-Catalyzed C−H iodination using molecular I2 as the sole oxidant. J. Am. Chem. Soc., 2013, 135, 10326.
(22) 胡燚, 杨姣, 唐苏苏, 初旭明, 邹彬, 黄和*. 氨基功能化离子液体修饰的SBA-15共价固定Burkholderia cepacia脂肪酶. 高等学校化学学报, 2013, 34, 1195.
(23) 丁雁, 黄和, 胡燚*. 脂肪酶催化C-C键形成反应研究进展. 有机化学, 2013, 33, 905.
(24) Yi Hu, Susu Tang, Ling Jiang, Bin Zou, Jiao Yang, He Huang*. Immobilization of Burkholderia cepacia lipase on functionalized ionic liquids modified mesoporous silica SBA-15. Process Biochem., 2012, 47, 2291.
(25) Susu Tang, Yi Hu*, Dinghua Yu, Bin Zou, Ling Jiang, Immobilization of Burkholderia cepacia lipase on functionalized ionic liquids modified mesoporous silica SBA-15. Chin. J. Catal., 2012, 33, 1565.
(26) Weiming Liu, Yi Hu, Ling Jiang, Bin Zou, He Huang*, Synthesis of methyl (R)-3-(4-fluorophenyl)glutarate via enzymatic desymmetrization of a prochiral diester. Process Biochem., 2012, 47,1037.
(27) Bin Zou, Yi Hu*, Dinghua Yu, Ling Jiang, Weiming Liu, Ping Song, Functional ionic liquid modified mesoporous silica SBA-15: a novel, designable and efficient carrier for porcine pancreas lipase. Colloids and Surface B: Biointerfaces, 2011, 93.
(28) Bin Zou, Yi Hu, Dinghua Yu, Jiaojiao Xia, Susu Tang, Weiming Liu, He Huang*. Immobilization of porcine pancreatic lipase onto ionic liquid modified mesoporous silica SBA-15. Biochem. Eng. J., 2010, 53, 150.
(29) Yi Hu, Weiming Liu, Bin Zou, Susu Tang, He Huang*. Enzyme immobilization on mesoporous materials. Prog. Chem., 2010, 22, 1656.
(30) Yaochi Hu, Nina Zhan, Chang Dou, He Huang, Yuwang Han, Dinghua Yu, Yi Hu*. Selective dehydration of bio-ethanol to ethylene catalyzed by lanthanum-phosphorous-modified HZSM-5: influence of the fusel. Biotechnol. J., 2010, 11, 1186.
(31) Nina Zhan, Yi Hu, Heng Li, Dinghua Yu, Yuwang Han, He Huang*. Lanthanum-phosphorous modified HZSM-5 catalysts in dehydration of ethanolto ethylene: a comparative analysis. Catal. Commun., 2010, 11, 633.
(32) Yi Hu, Tao Xie, Kaimei Fu, Hui Kang, Ping Wei, He Huang*. A convenient synthesis of 5-arylidenethiazolidine-2,4-diones catalyzed by alkaline ionic liquid. Heterocycles, 2009, 78, 757.
(33)Yi Hu, Hui Kang, Biwen Zeng, Ping Wei, He Huang*. Facile synthesis of 3-arylidene-1,3-dihydroindol-2-ones catalyzed by brØnsted acidic ionic liquids. J. Chem. Res., 2008, 642.
(34) Yi Hu*, Heng Li, He Huang, Ping Wei. Advance of liquid-phase organic synthesis using functional ionic liquids as supports. Chin. J. Org. Chem., 2007, 27, 1188.
(35)Yi Hu*, Ping Wei, Pingkai Ouyang, ZhenChu Chen. Organic synthesis in ionic liquids: condensation of 3-methyl-1-phenyl-5-pyrazolone with carbonyl compounds catalyzed by ethylenediammonium diacetate (EDDA). Chin. Chem. Lett., 2006, 17, 299.
(36) Yi Hu*, Ping Wei, He Huang. Synthesis of 2-aminothiophenes on ionic liquids-phase-support using the Gewald reaction. Synth.Commun., 2006, 36, 1543.
(37) Yi Hu*, Ping Wei, He Huang, Shiqing Han. Microwave-assisted Gewald synthesis of 2-aminothiophenes using functional ionic liquid as soluble support. Heterocycles, 2006, 68, 375.

联系方式:025-58139942,huyi@njtech.edu.cn

 




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